TB-500 vs KPV

At a glance

TB-500

The active fragment of Thymosin β4, a naturally occurring actin-sequestering peptide. Studied alongside BPC-157 for its role in cell migration and tissue remodelling.

TB-500 is a 20-residue peptide with the molecular formula C212H350N56O78S and a molecular weight of 4963.44 g/mol, CAS registry number 77591-33-4. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.

TB-500 is a synthetic fragment corresponding to the active region of thymosin beta-4, a 43-amino-acid protein found in most human cell types. The fragment, not the full protein, is what research suppliers sell.

The 3 papers cited below are 2 animal studies and 1 review. None is a controlled study of TB-500 in humans, and this page does not claim otherwise.

Cited on the TB-500 page

1. Goldstein AL et al. (2012). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. PubMed 22074294 · SummaryReview of thymosin β4 as an actin-sequestering peptide, its role in wound healing and cardiac repair, and early clinical work.
2. Malinda KM et al. (1999). Thymosin beta4 accelerates wound healing. J Invest Dermatol. PubMed 10469335 · SummaryFull-thickness skin wounds in rats: thymosin β4 accelerated closure, re-epithelialisation and collagen deposition.
3. Bock-Marquette I et al. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. PubMed 15565145 · SummaryThymosin β4 activated integrin-linked kinase in cardiomyocytes and improved cardiac function after coronary ligation in mice.

KPV

The C-terminal tripeptide of α-melanocyte-stimulating hormone. A small, stable molecule studied extensively in inflammatory-pathway research.

KPV is a 3-residue peptide with the molecular formula C16H30N4O4 and a molecular weight of 342.44 g/mol, CAS registry number 67727-97-3. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.

KPV is the tripeptide Lys-Pro-Val, the C-terminal three residues of alpha-melanocyte-stimulating hormone (alpha-MSH). It is among the smallest peptides in routine research use.

The 2 papers cited below are 1 animal study and 1 review. None is a controlled study of KPV in humans, and this page does not claim otherwise.

Cited on the KPV page

1. Dalmasso G et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PubMed 18061177 · SummaryKPV is taken up by the PepT1 transporter in intestinal epithelial cells and reduced inflammation in two mouse colitis models.
2. Brzoska T et al. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. PubMed 18612139 · SummaryReview of α-MSH and its C-terminal tripeptide: anti-inflammatory mechanisms in vitro and in vivo.

Handling the two side by side

TB-500

• The sequence contains methionine, which oxidises in solution. Keep reconstituted material out of light and recap the vial promptly.
• Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.

KPV

• Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.

Where to go next

• TB-500 and KPV: full specifications, stability notes, references and the certificate for the lot in stock.
• Repair and recovery peptide comparison: how the whole group compares.
• How to read a certificate of analysis and the certificates page.