In brief
The only human study of ipamorelin cited on this site, and it is a pharmacokinetic one. Healthy male volunteers received one of five 15-minute intravenous infusions, and ipamorelin and growth hormone were measured in blood. Ipamorelin exposure rose in proportion to dose; the terminal half-life was about two hours, clearance 0.078 litres per hour per kilogram, and steady-state volume of distribution 0.22 litres per kilogram. Growth hormone rose in a single episode that peaked at about 40 minutes and then fell exponentially to negligible levels at every dose. The authors fitted an indirect-response model in which ipamorelin drives a finite burst of growth-hormone release; half-maximal stimulation occurred at 214 nanomoles per litre. Between-subject variability was larger for the hormone response than for the drug levels.
Study design
Dose-escalation pharmacokinetic and pharmacodynamic study: five intravenous infusion rates over 15 minutes, eight healthy men per level.
What it does not show
Intravenous infusion in healthy men, single administrations, hormone levels as the only outcome. It characterises disposition and the shape of the growth-hormone pulse; it is not an efficacy or safety study and says nothing about subcutaneous use.
A clinical trial tests a pharmaceutical form of a compound, in a defined patient group, under medical supervision, with a defined endpoint. None of that transfers to a research-grade vial, and this page does not suggest it does.
Where this paper is cited
- Ipamorelin — Pharmacokinetic–pharmacodynamic model in human volunteers: dose-dependent growth hormone release with a short plasma half-life.
Other papers cited for Ipamorelin
- Animal study Ipamorelin, the first selective growth hormone secretagogue Raun et al. (1998), Eur J Endocrinol
Further reading
- Research library: every paper cited on this site, by compound and by study type.
- Growth hormone secretagogue comparison
- How to read a certificate of analysis
- Lyophilised peptide storage and stability
How this page was made: the citation was retrieved from PubMed by PMID and checked against the title on the product page; the summary was written from the paper's abstract and reports only what the abstract reports. Read the paper itself before relying on any figure here.