In brief
The Zagreb group reviews its own work on BPC 157 from the standpoint of the brain-gut axis: the idea that a peptide native to the gut could influence the central nervous system from the periphery. BPC 157 is presented as a possible mediator of cytoprotection that maintains the integrity of the gut lining, with reported effects in gastrointestinal, periodontal, liver and pancreatic lesions and in wound healing, and with the Egr-1, NAB2, FAK-paxillin and JAK-2 pathways implicated. Given peripherally, it altered serotonin release in particular brain regions and modulated serotonergic and dopaminergic systems, with effects on behavioural disturbances produced by over-stimulated or damaged neurotransmitter systems. Neuroprotective findings listed include somatosensory neurons, regeneration after peripheral nerve transection, and traumatic brain and spinal-cord injury in rats.
Study design
Review of the originating group's BPC 157 research, framed around the brain-gut axis.
What it does not show
A self-review of rodent studies. The multiple-sclerosis trial it mentions as under way has not produced a published efficacy result, and none of the neurological findings are from human studies.
A review summarises other papers and inherits every limit of the work it cites. It adds no new experiment, and where a review is written by the group that developed the compound, the selection of what to include is theirs.
Where this paper is cited
- BPC-157 — Review of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
- BPC-157 + TB-500 — Review of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
- GHK-Cu + BPC-157 + TB-500 + KPV — Review of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
Other papers cited for BPC-157, BPC-157 + TB-500 and GHK-Cu + BPC-157 + TB-500 + KPV
- Animal study PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation Dalmasso et al. (2008), Gastroenterology
- Cell-culture study The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration Chang et al. (2011), J Appl Physiol (1985)
- Review GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration Pickart et al. (2015), Biomed Res Int
- Review Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications Goldstein et al. (2012), Expert Opin Biol Ther
- Review Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract Sikiric et al. (2011), Curr Pharm Des
Further reading
- Research library: every paper cited on this site, by compound and by study type.
- Repair and recovery peptide comparison
- How to read a certificate of analysis
- Lyophilised peptide storage and stability
How this page was made: the citation was retrieved from PubMed by PMID and checked against the title on the product page; the summary was written from the paper's abstract and reports only what the abstract reports. Read the paper itself before relying on any figure here.