At a glance
| BPC-157 | GHK-Cu | |
|---|---|---|
| What it is | Body Protection Compound · Pentadecapeptide | Copper Peptide · Copper tripeptide-1 |
| Group | Repair & Recovery | Peptide Blends |
| Residues | 15 | — |
| Molecular formula | C62H98N16O22 | C14H22N6O4·Cu |
| Molecular weight | 1419.53 g/mol | 403.94 g/mol |
| CAS | 137525-51-0 | 89030-95-5 |
| Cited literature | No human study cited | No human study cited |
| Studies cited | 0 human · 0 animal · 1 cell · 2 review | 0 human · 0 animal · 1 cell · 2 review |
| Certificate | Third-party report for lot CS-bc10-0309, 99.789% purity, verification key VXXPES78PYD3 | Third-party report for lot CS-gu50-0309, 99.780% purity, verification key F8MIBZFZW3YP |
| Sizes and price | 10mg $80 | 50mg $40 · 100mg $80 |
| Availability | In stock | In stock |
| Storage | Lyophilised, −20°C, dark | Lyophilised, −20°C, dark |
BPC-157
A synthetic pentadecapeptide derived from a protective protein found in gastric juice. One of the most widely requested compounds in soft-tissue and gastrointestinal research models.
BPC-157 is a 15-residue peptide with the molecular formula C62H98N16O22 and a molecular weight of 1419.53 g/mol, CAS registry number 137525-51-0. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.
The name is short for Body Protection Compound. The 15-residue sequence was identified in a protein present in human gastric juice. It has been studied almost entirely in animal and cell models and holds no regulatory approval for human use anywhere.
The 3 papers cited below are 1 cell-culture study and 2 reviews. None is a controlled study of BPC-157 in humans, and this page does not claim otherwise.
Cited on the BPC-157 page
- Sikiric P et al. (2016). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. PubMed 27138887 · SummaryReview of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
- Chang CH et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). PubMed 21030672 · SummaryRat Achilles tendon fibroblasts in culture: BPC 157 increased outgrowth, survival and migration, via the FAK–paxillin pathway.
- Sikiric P et al. (2011). Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. PubMed 21548867 · SummaryReview of BPC 157 in gastrointestinal-tract injury models, including ulcer, fistula and anastomosis healing in rodents.
GHK-Cu
A naturally occurring copper-binding tripeptide with a deep, distinctive blue colour in solution. The most studied compound in dermal and follicular research.
GHK-Cu is the copper(II) complex of the tripeptide Gly-His-Lys with the molecular formula C14H22N6O4·Cu and a molecular weight of 403.94 g/mol, CAS registry number 89030-95-5. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.
GHK-Cu was identified by Loren Pickart in 1973 as a component of human plasma. Its concentration in plasma is documented to decline with age, which is the observation most of the research literature starts from.
The 3 papers cited below are 1 cell-culture study and 2 reviews. None is a controlled study of GHK-Cu in humans, and this page does not claim otherwise.
Cited on the GHK-Cu page
- Pickart L et al. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. PubMed 26236730 · SummaryReview of GHK as a modulator of gene expression, collagen synthesis and wound-healing pathways in skin.
- Pickart L & Margolina A (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. PubMed 29986520 · SummaryReview of GHK-Cu against the Broad Institute gene-expression data: which gene sets it appears to reset.
- Maquart FX et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. PubMed 3169264 · SummaryFibroblast cultures: the GHK–copper complex stimulated collagen synthesis at nanomolar concentrations.
Handling the two side by side
BPC-157
- Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.
GHK-Cu
- Supplied as a copper complex; the blue colour is the complex itself. Keep it away from chelating buffers and reducing agents.
- Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.
Where to go next
- BPC-157 and GHK-Cu: full specifications, stability notes, references and the certificate for the lot in stock.
- Repair and recovery peptide comparison: how the whole group compares.
- How to read a certificate of analysis and the certificates page.