BPC-157 vs KPV

At a glance

BPC-157

A synthetic pentadecapeptide derived from a protective protein found in gastric juice. One of the most widely requested compounds in soft-tissue and gastrointestinal research models.

BPC-157 is a 15-residue peptide with the molecular formula C62H98N16O22 and a molecular weight of 1419.53 g/mol, CAS registry number 137525-51-0. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.

The name is short for Body Protection Compound. The 15-residue sequence was identified in a protein present in human gastric juice. It has been studied almost entirely in animal and cell models and holds no regulatory approval for human use anywhere.

The 3 papers cited below are 1 cell-culture study and 2 reviews. None is a controlled study of BPC-157 in humans, and this page does not claim otherwise.

Cited on the BPC-157 page

1. Sikiric P et al. (2016). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. PubMed 27138887 · SummaryReview of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
2. Chang CH et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). PubMed 21030672 · SummaryRat Achilles tendon fibroblasts in culture: BPC 157 increased outgrowth, survival and migration, via the FAK–paxillin pathway.
3. Sikiric P et al. (2011). Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. PubMed 21548867 · SummaryReview of BPC 157 in gastrointestinal-tract injury models, including ulcer, fistula and anastomosis healing in rodents.

KPV

The C-terminal tripeptide of α-melanocyte-stimulating hormone. A small, stable molecule studied extensively in inflammatory-pathway research.

KPV is a 3-residue peptide with the molecular formula C16H30N4O4 and a molecular weight of 342.44 g/mol, CAS registry number 67727-97-3. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.

KPV is the tripeptide Lys-Pro-Val, the C-terminal three residues of alpha-melanocyte-stimulating hormone (alpha-MSH). It is among the smallest peptides in routine research use.

The 2 papers cited below are 1 animal study and 1 review. None is a controlled study of KPV in humans, and this page does not claim otherwise.

Cited on the KPV page

1. Dalmasso G et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PubMed 18061177 · SummaryKPV is taken up by the PepT1 transporter in intestinal epithelial cells and reduced inflammation in two mouse colitis models.
2. Brzoska T et al. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. PubMed 18612139 · SummaryReview of α-MSH and its C-terminal tripeptide: anti-inflammatory mechanisms in vitro and in vivo.

Handling the two side by side

BPC-157

• Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.

KPV

• Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.

Where to go next

• BPC-157 and KPV: full specifications, stability notes, references and the certificate for the lot in stock.
• Repair and recovery peptide comparison: how the whole group compares.
• How to read a certificate of analysis and the certificates page.