At a glance
| BPC-157 | TB-500 | |
|---|---|---|
| What it is | Body Protection Compound · Pentadecapeptide | Thymosin β4 Acetate · also listed as TP-500 |
| Group | Repair & Recovery | Repair & Recovery |
| Residues | 15 | 20 |
| Molecular formula | C62H98N16O22 | C212H350N56O78S |
| Molecular weight | 1419.53 g/mol | 4963.44 g/mol |
| CAS | 137525-51-0 | 77591-33-4 |
| Cited literature | No human study cited | No human study cited |
| Studies cited | 0 human · 0 animal · 1 cell · 2 review | 0 human · 2 animal · 0 cell · 1 review |
| Certificate | Third-party report for lot CS-bc10-0309, 99.789% purity, verification key VXXPES78PYD3 | Manufacturer certificate on request; no third-party report for the lot in stock yet |
| Sizes and price | 10mg $80 | 10mg $80 (out of stock) |
| Availability | In stock | Out of stock |
| Storage | Lyophilised, −20°C, dark | Lyophilised, −20°C, dark |
BPC-157
A synthetic pentadecapeptide derived from a protective protein found in gastric juice. One of the most widely requested compounds in soft-tissue and gastrointestinal research models.
BPC-157 is a 15-residue peptide with the molecular formula C62H98N16O22 and a molecular weight of 1419.53 g/mol, CAS registry number 137525-51-0. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.
The name is short for Body Protection Compound. The 15-residue sequence was identified in a protein present in human gastric juice. It has been studied almost entirely in animal and cell models and holds no regulatory approval for human use anywhere.
The 3 papers cited below are 1 cell-culture study and 2 reviews. None is a controlled study of BPC-157 in humans, and this page does not claim otherwise.
Cited on the BPC-157 page
- Sikiric P et al. (2016). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. PubMed 27138887 · SummaryReview of the animal literature on BPC 157 across gastrointestinal, vascular and nervous-system models, framed around the brain–gut axis.
- Chang CH et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). PubMed 21030672 · SummaryRat Achilles tendon fibroblasts in culture: BPC 157 increased outgrowth, survival and migration, via the FAK–paxillin pathway.
- Sikiric P et al. (2011). Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. PubMed 21548867 · SummaryReview of BPC 157 in gastrointestinal-tract injury models, including ulcer, fistula and anastomosis healing in rodents.
TB-500
The active fragment of Thymosin β4, a naturally occurring actin-sequestering peptide. Studied alongside BPC-157 for its role in cell migration and tissue remodelling.
TB-500 is a 20-residue peptide with the molecular formula C212H350N56O78S and a molecular weight of 4963.44 g/mol, CAS registry number 77591-33-4. The vial is sealed and lot-numbered, holds lyophilised powder, and is kept at −20°C protected from light until it ships.
TB-500 is a synthetic fragment corresponding to the active region of thymosin beta-4, a 43-amino-acid protein found in most human cell types. The fragment, not the full protein, is what research suppliers sell.
The 3 papers cited below are 2 animal studies and 1 review. None is a controlled study of TB-500 in humans, and this page does not claim otherwise.
Cited on the TB-500 page
- Goldstein AL et al. (2012). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. PubMed 22074294 · SummaryReview of thymosin β4 as an actin-sequestering peptide, its role in wound healing and cardiac repair, and early clinical work.
- Malinda KM et al. (1999). Thymosin beta4 accelerates wound healing. J Invest Dermatol. PubMed 10469335 · SummaryFull-thickness skin wounds in rats: thymosin β4 accelerated closure, re-epithelialisation and collagen deposition.
- Bock-Marquette I et al. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. PubMed 15565145 · SummaryThymosin β4 activated integrin-linked kinase in cardiomyocytes and improved cardiac function after coronary ligation in mice.
Handling the two side by side
BPC-157
- Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.
TB-500
- The sequence contains methionine, which oxidises in solution. Keep reconstituted material out of light and recap the vial promptly.
- Lyophilised powder is stable for years at −20°C in the dark and tolerates days at ambient temperature in transit.
Where to go next
- BPC-157 and TB-500: full specifications, stability notes, references and the certificate for the lot in stock.
- Repair and recovery peptide comparison: how the whole group compares.
- How to read a certificate of analysis and the certificates page.